Pharmacology and Breastfeeding

Medications, drugs, herbs--all can affect breastfeeding and some are contraindicative to breastfeeding.  The good news is, very few demand cessation of breastfeeding and information about drugs is readily available on a number of reputable websites.

I want to offer some general guidelines since those sitting for the exam will not be able to "Google" medications during the course of answering the multiple choice questions.

As a general rule, many medications are compatible with breastfeeding, but selecting the "safest" medications is advisable.  The aveolar epithelium of the breast is a lipid barrier that is most permeable in the first few days of lactation (when colostrum is produced). The transfer of water-soluble drugs and ions is inhibited by the hydorphobic barrier.  Water-soluble materials pass through pores in the basement membrane and para cellular spaces.  Drugs that have low lipid solubility and are non ionized will diminish its excretion into milk.
Medications should also be avoided the first 5-7 weeks postpartum, if possible.  During the early postpartum period the free fraction of some drugs increases and more readily crosses into the milk.(Lawrence & Lawrence, Breastfeeding a Guide for the Medical Profession, 6th Edition)

Some basic considerations for drug interaction with breastmilk includes:

• Route of administration

The route of administration (your baby is always exposed through the GI tract, but drugs can enter your system several different ways: orally, intravenously, intramuscularly, topically, or through inhalation - topical medications (skin creams) and medications inhaled or applied to the eyes or nose reach the milk in lesser amounts and more slowly than other routes and are almost always safe for nursing mothers; oral medications take longer to get into the milk than IV and IM routes (the drug must first go through the mother's GI tract before it enters the bloodstream, and the milk supply)-with IV drugs, the medications bypasses the barriers in the GI tract to enter the milk quickly and at higher levels, and with IM injections, drugs transfer quickly into the milk because the muscles have so many blood vessels, so the drug enters the bloodstream quickly. http://www.breastfeedingbasics.com/html/drugs_and_bf.shtml

• Absorption rate
• Half-life (choose medications with short half-lives and take immediately after nursing)
• Molecular weight (choose medications with high molecular weights)
• Maternal plasma level (higher maternal plasma levels result in higher milk levels)
• Ionization (choose medications that are ion trapped)
• Dosage (higher dosage has a greater chance transferring into the milk)
• pKa (choose drugs with a lower pKa)
• Solubility (high liquid solubility penetrate the milk in higher concentrations)
• Protein binding (desire high protein binding)

A good reference including reputable links is http://www.aap.org/breastfeeding/files/pdf/Lactmed.pdf
Medications listed as safe (categorized by lactation risk L1-L5) http://www.kellymom.com/health/meds/aap-approved-meds.html
For a list of medications contraindicative to breastfeeding visit http://www.breastfeeding-magazine.com/Unsafe-Drugs-and-Medications.html

Galactagogues, lactagogues and herbs must also must be closely monitored and dosage must be carefully calculated.  Just because they are not classified as drugs and FDA approved does not mean they are safe.  Many moms will try to self-medicate and they must be warned of the danger of the over-use of such herbs.

Birth control with progesterone only is a better option for mothers desiring to use a pill.  Barrier methods are compatible with breastfeeding and the LAM method is also effective if used correctly.

I highly recommend having a copy of Dr. Thomas Hale's Mother's Milk and Medications in your personal library.  Reading the preface of the newest edition will shed a lot of light on medications and how they interact and pass into the baby's blood stream.  Never give advice or perscribe any medication, this blog is for information only and should be used to form some basic understanding of drugs and how they are categorized.

When a mom contacts me about a medication, I initially look it up, see if there is a safer alternative and then suggest she ask her doctor if the other medication would be a plausible alternative to treat her condition and if it would be compatible with breastfeeding.  I also photocopy or print the information about the drug or direct her to the appropriate website.  I never recommend any medication or advise a mom not to take a medication that has been prescribed, that is outside of my scope as an IBCLC

This blog is for informational purposes only.  For medical advice, consult a medical professional.

Biochemistry of Human Milk

Biochemistry is the study of the structure, composition, and chemical reactions of substances in living systems. Biochemistry emerged as a separate discipline when scientists combined biology with organic, inorganic, or physical chemistry and began to study such topics as how living things obtain energy from food, the chemical basis of heredity, and what fundamental changes occur in disease. Biochemistry includes the sciences of molecular biology; immunochemistry; neurochemistry; and bioinorganic, bioorganic, and biophysical chemistry.

With the broad definition of biochemistry, it is obvious that a blog cannot do human milk justice, but I do have some points to share. I have been fascinated with this topic since I began my work in lactation.  In fact, one of my early projects was creating a visual that would allow parents to see in a snap shot how unique breastmilk is. I had seen a list of basic ingredients found in breastmilk compared to those in artificial human milk (formula).  I commenced to build a 3D image of my understanding and the "Lego Stack or Brick Building Block" emerged from my work.  I invented this tool back in 2001 and it has traveled across the US and is used in California WIC instructional material.  I am including a picture of the handout that accompanies the curriculum here, but the idea is to use a set of large building blocks (or duplo legos) and place one "ingredient" on top of the other as the properties of the ingredients are discussed.  At the end of the demo, the breastmilk stack dwarfs the formula stack.  It leaves quite the impression.

Since I created this simple illustration, I have learned so much more about breastmilk's composition.  I wish I could share my entire PowerPoint on Human Milk for Human Babies, but I will do my best to highlight some of the information.  One main  point is that human milk is species-specific.  Just a comparison of different mammals and their milk composition verifies this statement.  If we were to be fair and pick the mammal whose milk has many of the same ingredient percentages as humans, we would most likely be giving our infants donkey or cat milk.  I can't imagine having cat farms of lactating felines to feed our infants, but really, what's the difference between that and cattle farms?  Just a little regression to point out the humor in our loyalty to cow's milk formula.  


Breastmilk, unlike formula is a living organism.  When one looks at breastmilk under a microscope there is plenty of movement.  Contrast that with formula, where the petri dish reveals a stagnant state.  Formula is dead.  It cannot change to meet the needs of a particular infant.  It does not change during a feed.  In fact, the first drop given to an infant at day one is mirrored in the last drop he receives at one year.  Formula companies are now trying to market this change by creating "stage formulas", another gimmick for marketing. (I recently saw a formula ad that stated, "now, one step closer to breastmilk."  Here is a way to put that claim in perspective, stand at attention, move one step to the right and then declare, "I am now one step closer to China"--not anywhere near China, mind you, but able to make an honest statement, providing your geography is correct.  We have to all be aware of the claims marketing experts are making and be ready to expose the propaganda being used).


There are many articles that are well cited available for purchase.  These are the scholarly articles that appeal to the medical professionals and are written in journal language.  A few such articles are found at
http://www.ajcn.org/content/42/6/1299.abstract
http://www.springerlink.com/content/q33725u6p1530587/
http://www.ncbi.nlm.nih.gov/pubmed/6475139
http://www.askdrsears.com/html/2/t020800.asp


No study on milk composition is complete without mention of Marsha Walker's "Just One Bottle" paper  http://www.massbfc.org/formula/bottle.html
For those wanting some basic information on the biochemistry of human milk in order to be prepared for possible questions on the IBCLC Exam, every candidate should be familiar with the following facts:

• Colostrum is high in protein, fat-soluble vitamins (A and E), minerals, and immunoglobulins. (antibodies that pass from the mother to the baby and provide passive immunity for the baby. Passive immunity protects the baby from a wide variety of bacterial and viral illnesses). 
• Two to four days after birth, colostrum will be replaced by transitional milk in the full-term infant.
• Colostrum's primary function is protective due to high immunological factors
• Colostrum coats the sterile gut and protects from pathogens
• Colostrum is lower in fat than mature milk
• Secretory immunoglobulin A (SIgA) is highest in colostrum
• Colostrum creates a laxative effect aiding in the elimination of bilirubin (reducing jaundice)
• Transitional milk occurs after colostrum and lasts for approximately two weeks. The content of transitional milk includes high levels of fat, lactose, water-soluble vitamins, and contains more calories than colostrum.
• Mature milk is the final milk that is produced. 85-90% is water, which is necessary to maintain hydration of the infant. The other 10-15% is comprised of carbohydrates, proteins, and fats which are necessary for both growth and energy. There are two types of mature milk: foremilk and hind-milk.
• Human milk is higher in whey protein (cow's milk is higher in casein)
• Human milk has the lowest total protein 
• Human milk has 19 amino acids (for development)
• Human milk has over 40 identified enzymes (aid in digestion)
• Human milk is highest in lactose (carbohydrate) of all mammals (humans have the largest brain of all mammals at birth)
• There is not much iron in human milk, but infants are born with a large physiologic stores (enough to last 6 months).  These stores are laid down the last trimester, so if an infant went to term, there is likely enough iron to avoid any supplements.  Also, infants absorb 50% of the iron found in breastmilk, but only 4% of the iron in formula and cereals, so it is misleading to point out that formula has more iron since it is not readily available to the infant.  

Obviously, I could go on and on.  In fact, more ingredients are discovered in breastmilk annually. As money is put into lactation research, this list will most definitely be expounded on.  I liken it to our space explorations and discoveries.  I remember in elementary school learning about the Milky Way as the only galaxy and now as I study with my children I am reminded that new planets, stars, other galaxies--have all recently been discovered and what we thought was an exhaustive list of space was actually very anemic compared to recent finding through exploration.  Stay tuned in to research and attend conferences where newly published information is presented.  This is fascinating stuff!  

Humans are obviously made to breastfeed.  Mom's milk is perfect for her individual infant(s).  My new tagline is, "designed to breastfeed." Isn't it nice when we do what we are designed to do?  I recently tried to hammer a nail with a heel of my shoe--it worked, but when I used a small hammer, it was much more effective.

Christy Jo Hendricks, IBCLC, Doula

http://www.birthingandbreastfeeding.com/